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TargetRAC-alpha serine/threonine-protein kinase
LigandBDBM50246750
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1676766 (CHEMBL4026909)
Kd 3620±n/a nM
Citation Shi, Y; Challa, S; Sang, P; She, F; Li, C; Gray, GM; Nimmagadda, A; Teng, P; Odom, T; Wang, Y; van der Vaart, A; Li, Q; Cai, J One-Bead-Two-Compound Thioether Bridged Macrocyclic?-AApeptide Screening Library against EphA2. J Med Chem60:9290-9298 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAC-alpha serine/threonine-protein kinase
Name:RAC-alpha serine/threonine-protein kinase
Synonyms:AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:Enzyme
Mol. Mass.:55681.25
Organism:Homo sapiens (Human)
Description:P31749
Residue:480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50246750
n/a
NameBDBM50246750
Synonyms:CHEMBL4071045
TypeSmall organic molecule
Emp. Form.C96H110N12O23S2
Mol. Mass.1864.097
SMILESNC(=O)[C@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)NC(=O)CN1C[C@H](Cc2ccccc2)NC(=O)CN(C[C@H](CCC(O)=O)NC(=O)CN(C[C@H](CCC(O)=O)NC(=O)CN(C[C@H](Cc2ccccc2)NC(=O)c2ccc(CSCCC1=O)cc2)C(=O)CCC1CCCCC1)C(=O)Cc1ccc2OCOc2c1)C(=O)CCC(O)=O |r,wU:69.74,57.62,81.86,43.47,3.40,(24.07,-26.19,;22.75,-25.4,;21.41,-26.16,;22.76,-23.86,;24.1,-23.11,;25.43,-23.89,;26.77,-23.13,;28.1,-23.91,;29.44,-23.15,;30.76,-23.94,;30.75,-25.48,;32.1,-23.18,;33.43,-23.96,;34.76,-23.2,;36.09,-23.97,;36.08,-25.52,;34.74,-26.28,;33.41,-25.5,;33.95,-27.6,;34.71,-28.95,;32.41,-27.59,;37.4,-26.3,;38.74,-25.54,;38.75,-24.01,;40.09,-23.25,;41.42,-24.03,;42.76,-23.27,;41.4,-25.57,;40.06,-26.32,;40.05,-27.87,;38.71,-28.62,;38.69,-30.15,;37.35,-30.89,;37.32,-32.43,;36.04,-30.1,;36.05,-28.6,;37.39,-27.83,;21.43,-23.08,;21.45,-21.54,;22.79,-20.78,;20.12,-20.76,;20.14,-19.22,;21.47,-20,;22.73,-19.23,;24.17,-19.94,;25.64,-19.48,;26.76,-20.53,;28.23,-20.07,;28.57,-18.57,;27.43,-17.52,;25.96,-17.99,;22.62,-17.2,;23.95,-16.42,;25.29,-17.18,;23.94,-14.88,;22.6,-14.12,;22.58,-12.58,;21.24,-11.82,;21.23,-10.28,;22.56,-9.5,;22.55,-7.96,;21.21,-7.2,;23.87,-7.18,;19.92,-12.6,;18.58,-11.85,;18.56,-10.31,;17.25,-12.63,;15.91,-11.87,;14.58,-12.65,;13.24,-11.89,;13.23,-10.35,;11.89,-9.59,;11.88,-8.05,;13.2,-7.27,;10.54,-7.29,;11.92,-12.67,;10.58,-11.91,;10.56,-10.37,;9.25,-12.69,;9.26,-14.23,;8.16,-15.32,;8.15,-16.86,;6.81,-17.63,;5.48,-16.85,;5.5,-15.31,;4.17,-14.53,;2.83,-15.3,;2.83,-16.84,;4.16,-17.61,;9.48,-17.64,;9.47,-19.18,;8.14,-19.94,;10.8,-19.96,;10.79,-21.49,;12.12,-22.27,;13.46,-21.51,;14.79,-22.28,;16.13,-21.52,;16.13,-19.98,;17.47,-19.21,;18.8,-19.99,;18.79,-21.53,;13.46,-19.96,;12.13,-19.19,;7.93,-13.46,;7.93,-11.92,;6.59,-14.23,;5.25,-13.45,;5.28,-11.91,;6.62,-11.16,;6.63,-9.62,;5.31,-8.84,;3.97,-9.59,;3.95,-11.12,;15.9,-10.33,;14.56,-9.57,;17.22,-9.55,;17.21,-8.01,;15.87,-7.26,;15.85,-5.72,;17.19,-4.93,;17.5,-3.42,;19.03,-3.25,;19.67,-4.66,;18.53,-5.69,;18.54,-7.23,;23.93,-13.34,;23.91,-11.8,;25.27,-14.1,;26.59,-13.31,;27.93,-14.07,;29.26,-13.29,;27.95,-15.61,)|
Structure
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