| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 |
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| Ligand | BDBM50246758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1676770 (CHEMBL4026913) |
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| IC50 | 5000±n/a nM |
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| Citation |  Shi, Y; Challa, S; Sang, P; She, F; Li, C; Gray, GM; Nimmagadda, A; Teng, P; Odom, T; Wang, Y; van der Vaart, A; Li, Q; Cai, J One-Bead-Two-Compound Thioether Bridged Macrocyclic?-AApeptide Screening Library against EphA2. J Med Chem60:9290-9298 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 |
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| Name: | Ephrin type-A receptor 2 |
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| Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108260.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1505248 |
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| Residue: | 976 |
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| Sequence: | MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN
LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG
EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS
PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI
VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG
LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN
SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG
VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA
VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML
RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP
IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM
DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG
SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY
SLLGLKDQVNTVGIPI
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| BDBM50246758 |
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| n/a |
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| Name | BDBM50246758 |
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| Synonyms: | CHEMBL4093682 |
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| Type | Small organic molecule |
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| Emp. Form. | C69H87N9O17S |
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| Mol. Mass. | 1346.544 |
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| SMILES | NC(=O)CN1C[C@H](Cc2ccccc2)NC(=O)CN(C[C@H](CCC(O)=O)NC(=O)CN(C[C@H](CCC(O)=O)NC(=O)CN(C[C@H](Cc2ccccc2)NC(=O)c2ccc(CSCCC1=O)cc2)C(=O)CCC1CCCCC1)C(=O)Cc1ccc2OCOc2c1)C(=O)CCC(O)=O |r| |
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| Structure | 
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