Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50003350 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_138802 (CHEMBL751537) |
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IC50 | 187±n/a nM |
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Citation | Ward, JS; Merritt, L; Klimkowski, VJ; Lamb, ML; Mitch, CH; Bymaster, FP; Sawyer, B; Shannon, HE; Olesen, PH; Honoré, T Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. J Med Chem35:4011-9 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51390.46 |
Organism: | RAT |
Description: | P08482 |
Residue: | 460 |
Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50003350 |
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n/a |
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Name | BDBM50003350 |
Synonyms: | 5-(4-Heptyl-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine | 5-(4-Heptyl-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid | CHEMBL120399 | CHEMBL307837 |
Type | Small organic molecule |
Emp. Form. | C15H25N3S |
Mol. Mass. | 279.444 |
SMILES | CCCCCCCc1nsnc1C1=CCCN(C)C1 |t:13| |
Structure |
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