Reaction Details |
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Target | Folylpolyglutamate synthase, mitochondrial |
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Ligand | BDBM50003470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_68691 |
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Ki | 150±n/a nM |
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Citation | Hynes, JB; Singh, SK; Fetzer, O; Shane, B Inhibition of hog liver folylpolyglutamate synthetase by 5-substituted 5,8-dideaza analogues of folic acid bearing a terminal L-ornithine residue. J Med Chem35:4078-85 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Folylpolyglutamate synthase, mitochondrial |
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Name: | Folylpolyglutamate synthase, mitochondrial |
Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
Type: | PROTEIN |
Mol. Mass.: | 64621.95 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_68676 |
Residue: | 587 |
Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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BDBM50003470 |
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n/a |
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Name | BDBM50003470 |
Synonyms: | 5-Amino-2-{4-[(5-fluoro-2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanoic acid | CHEMBL339240 |
Type | Small organic molecule |
Emp. Form. | C22H24FN5O4 |
Mol. Mass. | 441.4555 |
SMILES | Cc1nc2ccc(NCc3ccc(cc3)C(=O)NC(CCCN)C(O)=O)c(F)c2c(=O)[nH]1 |
Structure |
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