Reaction Details |
| Report a problem with these data |
Target | Cytoplasmic tyrosine-protein kinase BMX |
---|
Ligand | BDBM291522 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1673716 (CHEMBL4023745) |
---|
IC50 | 38±n/a nM |
---|
Citation | Crawford, JJ; Johnson, AR; Misner, DL; Belmont, LD; Castanedo, G; Choy, R; Coraggio, M; Dong, L; Eigenbrot, C; Erickson, R; Ghilardi, N; Hau, J; Katewa, A; Kohli, PB; Lee, W; Lubach, JW; McKenzie, BS; Ortwine, DF; Schutt, L; Tay, S; Wei, B; Reif, K; Liu, L; Wong, H; Young, WB Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development. J Med Chem61:2227-2245 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytoplasmic tyrosine-protein kinase BMX |
---|
Name: | Cytoplasmic tyrosine-protein kinase BMX |
Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
Type: | Tyrosine-protein kinase |
Mol. Mass.: | 78030.42 |
Organism: | Homo sapiens (Human) |
Description: | P51813 |
Residue: | 675 |
Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
|
|
|
BDBM291522 |
---|
n/a |
---|
Name | BDBM291522 |
Synonyms: | 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one | US10413562, Compound A250 | US9580449, Example A250 | US9580449, Example A39 |
Type | Small organic molecule |
Emp. Form. | C25H27N5O2 |
Mol. Mass. | 429.5142 |
SMILES | Nc1ncnc(NCC2CCN(CC2)C(=O)C=C)c1-c1ccc(Oc2ccccc2)cc1 |
Structure |
|