Reaction Details |
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Target | Apelin receptor |
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Ligand | BDBM50244533 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1673874 (CHEMBL4023903) |
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Ki | 509±n/a nM |
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Citation | Trân, K; Murza, A; Sainsily, X; Coquerel, D; Côté, J; Belleville, K; Haroune, L; Longpré, JM; Dumaine, R; Salvail, D; Lesur, O; Auger-Messier, M; Sarret, P; Marsault, É A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects. J Med Chem61:2266-2277 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apelin receptor |
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Name: | Apelin receptor |
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42664.06 |
Organism: | Homo sapiens (Human) |
Description: | P35414 |
Residue: | 380 |
Sequence: | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
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BDBM50244533 |
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n/a |
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Name | BDBM50244533 |
Synonyms: | CHEMBL4075634 |
Type | Small organic molecule |
Emp. Form. | C69H103N19O15 |
Mol. Mass. | 1438.6744 |
SMILES | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1C\C=C/C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r,c:42| |
Structure |
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