Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM50244766 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1673964 (CHEMBL4023993) |
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Ki | 3.5±n/a nM |
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Citation | Yoshikawa, M; Saitoh, M; Katoh, T; Seki, T; Bigi, SV; Shimizu, Y; Ishii, T; Okai, T; Kuno, M; Hattori, H; Watanabe, E; Saikatendu, KS; Zou, H; Nakakariya, M; Tatamiya, T; Nakada, Y; Yogo, T Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem61:2384-2409 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 1 |
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Name: | Receptor-interacting serine/threonine-protein kinase 1 |
Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 75926.99 |
Organism: | Homo sapiens (Human) |
Description: | Q13546 |
Residue: | 671 |
Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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BDBM50244766 |
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n/a |
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Name | BDBM50244766 |
Synonyms: | CHEMBL4073321 |
Type | Small organic molecule |
Emp. Form. | C26H26ClN5O4 |
Mol. Mass. | 507.969 |
SMILES | CN(C)C(=O)c1ccc2N(C)C(=O)[C@H](COc2c1)N1CCc2c(Cl)n(Cc3ccccc3)nc2C1=O |r| |
Structure |
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