| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase subunit M2 |
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| Ligand | BDBM50198892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1677703 (CHEMBL4027846) |
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| IC50 | 185±n/a nM |
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| Citation |  Huff, SE; Mohammed, FA; Yang, M; Agrawal, P; Pink, J; Harris, ME; Dealwis, CG; Viswanathan, R Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem61:666-680 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonucleoside-diphosphate reductase subunit M2 |
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| Name: | Ribonucleoside-diphosphate reductase subunit M2 |
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| Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44868.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_195255 |
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| Residue: | 389 |
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| Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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| BDBM50198892 |
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| n/a |
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| Name | BDBM50198892 |
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| Synonyms: | 3-AP | 3-aminopyridine-2-carboxaldehyde thiosemicarbazone | Triapine | US10155732, Compound 3-AP |
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| Type | Small organic molecule |
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| Emp. Form. | C7H9N5S |
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| Mol. Mass. | 195.245 |
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| SMILES | NC(=S)N\N=C\c1ncccc1N |
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| Structure | 
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