Compile Data Set for Download or QSAR

Found 44 hits with Last Name = 'viswanathan' and Initial = 'r'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247408 (CHEMBL4067105) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Competitive inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50198892 (3-AP | 3-aminopyridine-2-carboxaldehyde thiosemica...) Show SMILES NC(=S)N\N=C\c1ncccc1N Show InChI InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM2 expressed in Escherichia coli BL21-codon plus(DE3) using [14C]-ADP as substrate after 3 mins by liquid scintillation countin...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247442 (CHEMBL3193213) Show SMILES Oc1ccc2ccccc2c1\C=N\NC(=O)c1cccnc1 Show InChI InChI=1S/C17H13N3O2/c21-16-8-7-12-4-1-2-6-14(12)15(16)11-19-20-17(22)13-5-3-9-18-10-13/h1-11,21H,(H,20,22)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247435 (CHEMBL4073197) Show SMILES Nc1ccc(cc1Cl)C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H14ClN3O2/c19-15-9-12(5-7-16(15)20)18(24)22-21-10-14-13-4-2-1-3-11(13)6-8-17(14)23/h1-10,23H,20H2,(H,22,24)/b21-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247434 (CHEMBL1958235) Show SMILES Cc1ccc(cc1)S(=O)(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H16N2O3S/c1-13-6-9-15(10-7-13)24(22,23)20-19-12-17-16-5-3-2-4-14(16)8-11-18(17)21/h2-12,20-21H,1H3/b19-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247436 (CHEMBL4100050) Show SMILES Oc1ccc2cc(\C=N\NC(=O)c3ccccc3O)ccc2c1 Show InChI InChI=1S/C18H14N2O3/c21-15-8-7-13-9-12(5-6-14(13)10-15)11-19-20-18(23)16-3-1-2-4-17(16)22/h1-11,21-22H,(H,20,23)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247408 (CHEMBL4067105) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247441 (CHEMBL4067759) Show SMILES Cc1cccc2c(\C=N\NC(=O)c3ccccc3O)c[nH]c12 Show InChI InChI=1S/C17H15N3O2/c1-11-5-4-7-13-12(9-18-16(11)13)10-19-20-17(22)14-6-2-3-8-15(14)21/h2-10,18,21H,1H3,(H,20,22)/b19-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247433 (CHEMBL4059739) Show SMILES COc1cc(Br)ccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C19H15BrN2O3/c1-25-18-10-13(20)7-8-15(18)19(24)22-21-11-16-14-5-3-2-4-12(14)6-9-17(16)23/h2-11,23H,1H3,(H,22,24)/b21-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247432 (CHEMBL4077024) Show SMILES COc1ccc(Br)cc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C19H15BrN2O3/c1-25-18-9-7-13(20)10-15(18)19(24)22-21-11-16-14-5-3-2-4-12(14)6-8-17(16)23/h2-11,23H,1H3,(H,22,24)/b21-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247427 (CHEMBL4064659) Show SMILES Oc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(c(Cl)c1)[N+]([O-])=O Show InChI InChI=1S/C18H12ClN3O4/c19-15-9-12(5-7-16(15)22(25)26)18(24)21-20-10-14-13-4-2-1-3-11(13)6-8-17(14)23/h1-10,23H,(H,21,24)/b20-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247440 (CHEMBL4091609) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c[nH]c2ccc(cc12)[N+]([O-])=O Show InChI InChI=1S/C16H12N4O4/c21-15-4-2-1-3-12(15)16(22)19-18-9-10-8-17-14-6-5-11(20(23)24)7-13(10)14/h1-9,17,21H,(H,19,22)/b18-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247426 (CHEMBL4097201) Show SMILES Oc1ccc2[nH]cc(\C=N\NC(=O)c3ccccc3O)c2c1 Show InChI InChI=1S/C16H13N3O3/c20-11-5-6-14-13(7-11)10(8-17-14)9-18-19-16(22)12-3-1-2-4-15(12)21/h1-9,17,20-21H,(H,19,22)/b18-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247424 (CHEMBL4101599) Show SMILES Oc1ccc2ccccc2c1\C=N\Nc1ccc(Br)cc1 Show InChI InChI=1S/C17H13BrN2O/c18-13-6-8-14(9-7-13)20-19-11-16-15-4-2-1-3-12(15)5-10-17(16)21/h1-11,20-21H/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500167 (CHEMBL3747291) Show SMILES CCC(C)(C)c1ccc(OCCCCNC(=O)c2cc(Oc3ccc(cc3)[N+]([O-])=O)c3ccccc3c2O)c(c1)C(C)(C)CC Show InChI InChI=1S/C37H44N2O6/c1-7-36(3,4)25-15-20-32(31(23-25)37(5,6)8-2)44-22-12-11-21-38-35(41)30-24-33(28-13-9-10-14-29(28)34(30)40)45-27-18-16-26(17-19-27)39(42)43/h9-10,13-20,23-24,40H,7-8,11-12,21-22H2,1-6H3,(H,38,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500166 (CHEMBL3747319) Show SMILES CC(NCCCCCO)c1cc(OCc2ccccc2)cc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H33NO3/c1-22(28-15-9-4-10-16-29)25-17-26(30-20-23-11-5-2-6-12-23)19-27(18-25)31-21-24-13-7-3-8-14-24/h2-3,5-8,11-14,17-19,22,28-29H,4,9-10,15-16,20-21H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247425 (CHEMBL4070699) Show SMILES Nc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H15N3O2/c19-16-8-4-3-7-14(16)18(23)21-20-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,22H,19H2,(H,21,23)/b20-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500171 (CHEMBL600902 | GNF-Pf-721) Show SMILES OC(COc1ccc(OCC(O)CN2CCN(CC2)C2c3ccccc3-c3ccccc23)cc1)CN1CCN(CC1)C1c2ccccc2-c2ccccc12 Show InChI InChI=1S/C46H50N4O4/c51-33(29-47-21-25-49(26-22-47)45-41-13-5-1-9-37(41)38-10-2-6-14-42(38)45)31-53-35-17-19-36(20-18-35)54-32-34(52)30-48-23-27-50(28-24-48)46-43-15-7-3-11-39(43)40-12-4-8-16-44(40)46/h1-20,33-34,45-46,51-52H,21-32H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500170 (CHEMBL3747217) Show SMILES CCOC(=O)C[C@@H](CC(=O)NCCN[C@H](C)c1ccc(O)c(c1)C(=O)OC)OC(C)=O |r| Show InChI InChI=1S/C21H30N2O8/c1-5-30-20(27)12-16(31-14(3)24)11-19(26)23-9-8-22-13(2)15-6-7-18(25)17(10-15)21(28)29-4/h6-7,10,13,16,22,25H,5,8-9,11-12H2,1-4H3,(H,23,26)/t13-,16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247408 (CHEMBL4067105) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate by boronate affinity chromatography				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500168 (CHEMBL3746072) Show SMILES CC(C)(NC(=O)CN1C(=O)c2ccccc2C1=O)C(=O)NCCCC[C@H](NC(=O)CC(O)(C(F)(F)F)C(F)(F)F)C(O)=O |r| Show InChI InChI=1S/C25H28F6N4O8/c1-22(2,34-17(37)12-35-18(38)13-7-3-4-8-14(13)19(35)39)21(42)32-10-6-5-9-15(20(40)41)33-16(36)11-23(43,24(26,27)28)25(29,30)31/h3-4,7-8,15,43H,5-6,9-12H2,1-2H3,(H,32,42)(H,33,36)(H,34,37)(H,40,41)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500174 (CHEMBL3745866) Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)OC |r| Show InChI InChI=1S/C29H58N4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-22-27(34)32-25(20-16-18-23-30)28(35)33-26(29(36)37-2)21-17-19-24-31/h25-26H,3-24,30-31H2,1-2H3,(H,32,34)(H,33,35)/t25-,26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247439 (CHEMBL4075660) Show SMILES Oc1ccc2ccccc2c1\C=N\N=C\c1ccccc1 Show InChI InChI=1S/C18H14N2O/c21-18-11-10-15-8-4-5-9-16(15)17(18)13-20-19-12-14-6-2-1-3-7-14/h1-13,21H/b19-12+,20-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247423 (CHEMBL4064137) Show SMILES Oc1ccc2ccccc2c1\C=N\NS(=O)(=O)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C17H13N3O5S/c21-17-10-5-12-3-1-2-4-15(12)16(17)11-18-19-26(24,25)14-8-6-13(7-9-14)20(22)23/h1-11,19,21H/b18-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500165 (CHEMBL3746526) Show SMILES CCCOc1ccc(cc1NS(=O)(=O)\C=C\c1ccccc1)C(=O)OCCN(CC)CC Show InChI InChI=1S/C24H32N2O5S/c1-4-16-30-23-13-12-21(24(27)31-17-15-26(5-2)6-3)19-22(23)25-32(28,29)18-14-20-10-8-7-9-11-20/h7-14,18-19,25H,4-6,15-17H2,1-3H3/b18-14+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500172 (CHEMBL3746454) Show SMILES CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O |r| Show InChI InChI=1S/C34H53N11O8/c1-18(2)27(44-29(48)23(41-26(47)16-37-5)7-6-12-39-34(35)36)31(50)42-24(13-20-8-10-22(46)11-9-20)30(49)45-28(19(3)4)32(51)43-25(33(52)53)14-21-15-38-17-40-21/h8-11,15,17-19,23-25,27-28,37,46H,6-7,12-14,16H2,1-5H3,(H,38,40)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,45,49)(H,52,53)(H4,35,36,39)/t23-,24-,25-,27-,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500173 (CHEMBL3746940) Show SMILES CCCCCCCCCCCCCCNC(=O)[C@@H](N)CCN |r| Show InChI InChI=1S/C18H39N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21-18(22)17(20)14-15-19/h17H,2-16,19-20H2,1H3,(H,21,22)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500169 (CHEMBL3746715) Show SMILES CCOC(=O)C(NC(=O)CN[C@H]1CCCc2sccc12)C(=O)OCC |r| Show InChI InChI=1S/C17H24N2O5S/c1-3-23-16(21)15(17(22)24-4-2)19-14(20)10-18-12-6-5-7-13-11(12)8-9-25-13/h8-9,12,15,18H,3-7,10H2,1-2H3,(H,19,20)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247410 (CHEMBL4077097) Show SMILES Oc1ccc2ccccc2c1\C=N\Nc1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C17H13N3O3/c21-17-10-5-12-3-1-2-4-15(12)16(17)11-18-19-13-6-8-14(9-7-13)20(22)23/h1-11,19,21H/b18-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247411 (CHEMBL4087321) Show SMILES Cc1ccc(\C=N\N=C\c2c(O)ccc3ccccc23)cc1 Show InChI InChI=1S/C19H16N2O/c1-14-6-8-15(9-7-14)12-20-21-13-18-17-5-3-2-4-16(17)10-11-19(18)22/h2-13,22H,1H3/b20-12+,21-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247422 (CHEMBL4085702) Show SMILES COc1ccc(\C=N\N=C\c2c(O)ccc3ccccc23)cc1 Show InChI InChI=1S/C19H16N2O2/c1-23-16-9-6-14(7-10-16)12-20-21-13-18-17-5-3-2-4-15(17)8-11-19(18)22/h2-13,22H,1H3/b20-12+,21-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247412 (CHEMBL4074537) Show SMILES CN(C)c1ccc(\C=N\N=C\c2c(O)ccc3ccccc23)cc1 Show InChI InChI=1S/C20H19N3O/c1-23(2)17-10-7-15(8-11-17)13-21-22-14-19-18-6-4-3-5-16(18)9-12-20(19)24/h3-14,24H,1-2H3/b21-13+,22-14+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247437 (CHEMBL4065911) Show SMILES Oc1ccc2ccccc2c1\C=N\NC(=O)OCc1ccccc1 Show InChI InChI=1S/C19H16N2O3/c22-18-11-10-15-8-4-5-9-16(15)17(18)12-20-21-19(23)24-13-14-6-2-1-3-7-14/h1-12,22H,13H2,(H,21,23)/b20-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247421 (CHEMBL4102759) Show SMILES Oc1ccc2ccccc2c1\C=N\NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H14N2O3S/c20-17-11-10-13-6-4-5-9-15(13)16(17)12-18-19-23(21,22)14-7-2-1-3-8-14/h1-12,19-20H/b18-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50247408 (CHEMBL4067105) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM2 expressed in Escherichia coli BL21-codon plus(DE3) using [14C]-ADP as substrate after 3 mins by liquid scintillation countin...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247409 (CHEMBL4093660) Show SMILES Oc1ccc2ccccc2c1\C=N\NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C18H16N2O3S/c21-18-11-10-15-8-4-5-9-16(15)17(18)12-19-20-24(22,23)13-14-6-2-1-3-7-14/h1-12,20-21H,13H2/b19-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.31E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247438 (CHEMBL4084809) Show SMILES CC1(C)C2CC(CS(=O)(=O)N\N=C\c3c(O)ccc4ccccc34)C1C(=O)C2 |TLB:26:25:1:5.4,6:5:1:27.25| Show InChI InChI=1S/C21H24N2O4S/c1-21(2)15-9-14(20(21)19(25)10-15)12-28(26,27)23-22-11-17-16-6-4-3-5-13(16)7-8-18(17)24/h3-8,11,14-15,20,23-24H,9-10,12H2,1-2H3/b22-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.98E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247420 (CHEMBL4095000) Show SMILES COc1cc(\C=N\N=C\c2c(O)ccc3ccccc23)ccc1O Show InChI InChI=1S/C19H16N2O3/c1-24-19-10-13(6-8-18(19)23)11-20-21-12-16-15-5-3-2-4-14(15)7-9-17(16)22/h2-12,22-23H,1H3/b20-11+,21-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.87E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50017811 (CHEMBL467 | HU | US10155732, Compound HU | hydroxy...) Show SMILES NC(=O)NO Show InChI InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank Article PubMed	n/a	n/a	9.97E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500166 (CHEMBL3747319) Show SMILES CC(NCCCCCO)c1cc(OCc2ccccc2)cc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H33NO3/c1-22(28-15-9-4-10-16-29)25-17-26(30-20-23-11-5-2-6-12-23)19-27(18-25)31-21-24-13-7-3-8-14-24/h2-3,5-8,11-14,17-19,22,28-29H,4,9-10,15-16,20-21H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Binding affinity to human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500171 (CHEMBL600902 | GNF-Pf-721) Show SMILES OC(COc1ccc(OCC(O)CN2CCN(CC2)C2c3ccccc3-c3ccccc23)cc1)CN1CCN(CC1)C1c2ccccc2-c2ccccc12 Show InChI InChI=1S/C46H50N4O4/c51-33(29-47-21-25-49(26-22-47)45-41-13-5-1-9-37(41)38-10-2-6-14-42(38)45)31-53-35-17-19-36(20-18-35)54-32-34(52)30-48-23-27-50(28-24-48)46-43-15-7-3-11-39(43)40-12-4-8-16-44(40)46/h1-20,33-34,45-46,51-52H,21-32H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.56E+4	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Binding affinity to human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50247408 (CHEMBL4067105) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Binding affinity to human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL by fluorescence spectrophotometric method				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500168 (CHEMBL3746072) Show SMILES CC(C)(NC(=O)CN1C(=O)c2ccccc2C1=O)C(=O)NCCCC[C@H](NC(=O)CC(O)(C(F)(F)F)C(F)(F)F)C(O)=O |r| Show InChI InChI=1S/C25H28F6N4O8/c1-22(2,34-17(37)12-35-18(38)13-7-3-4-8-14(13)19(35)39)21(42)32-10-6-5-9-15(20(40)41)33-16(36)11-23(43,24(26,27)28)25(29,30)31/h3-4,7-8,15,43H,5-6,9-12H2,1-2H3,(H,32,42)(H,33,36)(H,34,37)(H,40,41)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	9.68E+3	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Binding affinity to human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human))	BDBM50500165 (CHEMBL3746526) Show SMILES CCCOc1ccc(cc1NS(=O)(=O)\C=C\c1ccccc1)C(=O)OCCN(CC)CC Show InChI InChI=1S/C24H32N2O5S/c1-4-16-30-23-13-12-21(24(27)31-17-15-26(5-2)6-3)19-22(23)25-32(28,29)18-14-20-10-8-7-9-11-20/h7-14,18-19,25H,4-6,15-17H2,1-3H3/b18-14+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	5.53E+4	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Binding affinity to human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay				J Med Chem 58: 9498-509 (2015) Article DOI: 10.1021/acs.jmedchem.5b00929 BindingDB Entry DOI: 10.7270/Q2MW2M5M
					More data for this Ligand-Target Pair