| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM107767 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1677919 (CHEMBL4028062) |
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| Ki | 4.2±n/a nM |
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| Citation |  Helal, CJ; Arnold, E; Boyden, T; Chang, C; Chappie, TA; Fisher, E; Hajos, M; Harms, JF; Hoffman, WE; Humphrey, JM; Pandit, J; Kang, Z; Kleiman, RJ; Kormos, BL; Lee, CW; Lu, J; Maklad, N; McDowell, L; McGinnis, D; O'Connor, RE; O'Donnell, CJ; Ogden, A; Piotrowski, M; Schmidt, CJ; Seymour, PA; Ueno, H; Vansell, N; Verhoest, PR; Yang, EX Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem61:1001-1018 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Synonyms: | PDE2A_RAT | Pde2a | Phosphodiesterase 2A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 104640.72 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_156330 |
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| Residue: | 928 |
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| Sequence: | MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAGLRQAAKD
ALSAVLPKVETVYTYLVDGESRLVCEDPPHELPQEGKIREAVISRKRLSCDGLGPSDLLG
KPLARLVAPLAPDTQVLVIPLLDKETGTVAAVILVHCGQLSDSEEQSLQVVEKHALVALQ
RVQALQQRRPEAVQNTSADPSEDQKDEKGYTAHDRKILQLCGELYDLDATSLQLKVLRYL
QQETQATHCCLLLVSEDNLQLSCKVIGEKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLT
SDDVQQLQNMLGCELRAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDERAIQHCFHY
TGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSV
FLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVD
DSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSL
LYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPE
DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY
KNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA
QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNN
KQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREK
AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNS
LDFLDEEYEVPDLDVTRAPVNGCCSLEG
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| BDBM107767 |
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| n/a |
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| Name | BDBM107767 |
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| Synonyms: | US11419874, PF-05180999 | US8598155, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17F3N8 |
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| Mol. Mass. | 414.3871 |
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| SMILES | Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1 |
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| Structure | 
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