| Reaction Details |
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 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
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| Ligand | BDBM4815 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1679543 (CHEMBL4029820) |
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| IC50 | 760±n/a nM |
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| Citation |  Edupuganti, R; Taliaferro, JM; Wang, Q; Xie, X; Cho, EJ; Vidhu, F; Ren, P; Anslyn, EV; Bartholomeusz, C; Dalby, KN Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem25:2609-2616 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Maternal embryonic leucine zipper kinase |
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| Name: | Maternal embryonic leucine zipper kinase |
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| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 74665.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14680 |
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| Residue: | 651 |
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| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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| BDBM4815 |
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| n/a |
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| Name | BDBM4815 |
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| Synonyms: | 5-{[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide | CHEMBL13485 | SU11248 analog 12c | US10981896, Compound 572660 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27ClN4O2 |
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| Mol. Mass. | 414.928 |
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| SMILES | CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(Cl)cc23)c1C |
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| Structure | 
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