| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50250203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1681326 (CHEMBL4031603) |
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| EC50 | 89±n/a nM |
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| Citation |  Palmer, D; Gonçalves, JPL; V Hansen, L; Wu, B; Hald, H; Schoffelen, S; Diness, F; Le Quement, ST; Nielsen, TE; Meldal, M Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists. J Med Chem60:8716-8730 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50250203 |
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| n/a |
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| Name | BDBM50250203 |
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| Synonyms: | CHEMBL4083755 |
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| Type | Small organic molecule |
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| Emp. Form. | C53H71N17O9S |
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| Mol. Mass. | 1122.304 |
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| SMILES | CSCC[C@H](NC(=O)[C@@H]1Cc2cn(C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N1)nn2)C(O)=O |r| |
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| Structure | 
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