| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
|---|
| Ligand | BDBM50006475 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_31769 |
|---|
| IC50 | 3.3±n/a nM |
|---|
| Citation |  Mylari, BL; Zembrowski, WJ; Beyer, TA; Aldinger, CE; Siegel, TW Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives. J Med Chem35:2155-62 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 |
|---|
| Name: | Aldo-keto reductase family 1 member B1 |
|---|
| Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35855.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
|---|
| Residue: | 316 |
|---|
| Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
|
|
|
|---|
| BDBM50006475 |
|---|
| n/a |
|---|
| Name | BDBM50006475 |
|---|
| Synonyms: | CHEMBL71966 | {1-[3-(2,3-Difluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-4,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14F2N4O4 |
|---|
| Mol. Mass. | 376.3143 |
|---|
| SMILES | Cc1c(C)c(=O)n(Cc2nc(no2)-c2cccc(F)c2F)nc1CC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
