| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50252383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1684771 (CHEMBL4035250) |
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| IC50 | 150±n/a nM |
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| Citation |  De Vreese, R; D'hooghe, M Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors. Eur J Med Chem135:174-195 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50252383 |
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| n/a |
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| Name | BDBM50252383 |
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| Synonyms: | CHEMBL4105617 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N2O2S2 |
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| Mol. Mass. | 342.435 |
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| SMILES | ONC(=O)c1cccc(c1)-c1csc(CSc2ccccc2)n1 |
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| Structure | 
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