| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50255235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1687006 (CHEMBL4037485) |
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| IC50 | 500±n/a nM |
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| Citation |  Aghazadeh Tabrizi, M; Baraldi, PG; Baraldi, S; Ruggiero, E; De Stefano, L; Rizzolio, F; Di Cesare Mannelli, L; Ghelardini, C; Chicca, A; Lapillo, M; Gertsch, J; Manera, C; Macchia, M; Martinelli, A; Granchi, C; Minutolo, F; Tuccinardi, T Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. J Med Chem61:1340-1354 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50255235 |
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| n/a |
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| Name | BDBM50255235 |
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| Synonyms: | CHEMBL4078924 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N3O2 |
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| Mol. Mass. | 465.586 |
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| SMILES | Cc1cccc(Cn2nc(cc2-c2ccc(O)cc2)C(=O)N2CCC(Cc3ccccc3)CC2)c1 |
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| Structure | 
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