Reaction Details |
| Report a problem with these data |
Target | Metabotropic glutamate receptor 8 |
---|
Ligand | BDBM50255338 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1687014 (CHEMBL4037493) |
---|
EC50 | 2500±n/a nM |
---|
Citation | Selvam, C; Lemasson, IA; Brabet, I; Oueslati, N; Karaman, B; Cabaye, A; Tora, AS; Commare, B; Courtiol, T; Cesarini, S; McCort-Tranchepain, I; Rigault, D; Mony, L; Bessiron, T; McLean, H; Leroux, FR; Colobert, F; Daniel, H; Goupil-Lamy, A; Bertrand, HO; Goudet, C; Pin, JP; Acher, FC Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem61:1969-1989 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Metabotropic glutamate receptor 8 |
---|
Name: | Metabotropic glutamate receptor 8 |
Synonyms: | GPRC1H | GRM8 | GRM8_HUMAN | MGLUR8 | Metabotropic glutamate receptor 8 | metabotropic glutamate 8 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 101759.58 |
Organism: | Homo sapiens (Human) |
Description: | metabotropic glutamate 8 GRM8 HUMAN::O00222 |
Residue: | 908 |
Sequence: | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
|
|
|
BDBM50255338 |
---|
n/a |
---|
Name | BDBM50255338 |
Synonyms: | CHEMBL4083240 |
Type | Small organic molecule |
Emp. Form. | C11H14ClN2O7P |
Mol. Mass. | 352.665 |
SMILES | N[C@@H](CCP(O)(=O)C(O)c1ccc(Cl)c(c1)[N+]([O-])=O)C(O)=O |r| |
Structure |
|