| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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| Ligand | BDBM50255714 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1687480 (CHEMBL4037959) |
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| Ki | 14±n/a nM |
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| Citation |  Kalbas, D; Liebscher, S; Nowak, T; Meleshin, M; Pannek, M; Popp, C; Alhalabi, Z; Bordusa, F; Sippl, W; Steegborn, C; Schutkowski, M Potent and Selective Inhibitors of Human Sirtuin 5. J Med Chem61:2460-2471 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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| Name: | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5 |
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| Type: | Protein |
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| Mol. Mass.: | 33892.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXA8 |
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| Residue: | 310 |
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| Sequence: | MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAG
VSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRA
IAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPI
CPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELA
HCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEA
LACHENETVS
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| BDBM50255714 |
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| n/a |
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| Name | BDBM50255714 |
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| Synonyms: | CHEMBL4064460 |
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| Type | Small organic molecule |
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| Emp. Form. | C78H116N14O21S2 |
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| Mol. Mass. | 1649.967 |
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| SMILES | [H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)C[C@H](Sc3ccc4ccccc4c3)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](C(C)C)C(N)=O)[C@@]1([H])NC(=O)N2 |r| |
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| Structure | 
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