| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
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| Ligand | BDBM50256824 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1688461 (CHEMBL4039031) |
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| IC50 | 2970±n/a nM |
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| Citation |  Yang, F; Xie, F; Zhang, Y; Xia, Y; Liu, W; Jiang, F; Lam, C; Qiao, Y; Xie, D; Li, J; Fu, L Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett27:2166-2170 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 2 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
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| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
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| Type: | Protein |
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| Mol. Mass.: | 48481.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17706 |
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| Residue: | 415 |
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| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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| BDBM50256824 |
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| n/a |
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| Name | BDBM50256824 |
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| Synonyms: | CHEMBL4087797 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H38ClNO10S2 |
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| Mol. Mass. | 804.324 |
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| SMILES | CCOS(=O)(=O)\C=C\c1ccc(OCc2ccc(COc3ccc(\C=C\S(=O)(=O)OCC)cc3)c(c2)C(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2)cc1 |
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| Structure | 
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