| Reaction Details |
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 | Report a problem with these data |
| Target | Inward rectifier potassium channel 2 |
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| Ligand | BDBM50257064 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1688715 |
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| IC50 | >100000±n/a nM |
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| Citation |  Felts, AS; Rodriguez, AL; Blobaum, AL; Morrison, RD; Bates, BS; Thompson Gray, A; Rook, JM; Tantawy, MN; Byers, FW; Chang, S; Venable, DF; Luscombe, VB; Tamagnan, GD; Niswender, CM; Daniels, JS; Jones, CK; Conn, PJ; Lindsley, CW; Emmitte, KA Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem60:5072-5085 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inward rectifier potassium channel 2 |
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| Name: | Inward rectifier potassium channel 2 |
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| Synonyms: | Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48281.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515520 |
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| Residue: | 427 |
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| Sequence: | MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK
ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM
AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG
EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD
LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI
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| BDBM50257064 |
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| n/a |
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| Name | BDBM50257064 |
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| Synonyms: | CHEMBL2386850 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12FN5O2 |
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| Mol. Mass. | 325.2972 |
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| SMILES | Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1 |
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| Structure | 
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