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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H4 receptor | ||
| Ligand | BDBM50259265 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1691274 (CHEMBL4041923) | ||
| Ki | 19±n/a nM | ||
| Citation |  Levoin, N; Labeeuw, O; Billot, X; Calmels, T; Danvy, D; Krief, S; Berrebi-Bertrand, I; Lecomte, JM; Schwartz, JC; Capet, M Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. Eur J Med Chem125:565-572 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H4 receptor | |||
| Name: | Histamine H4 receptor | ||
| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 44517.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. | ||
| Residue: | 390 | ||
| Sequence: |
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| BDBM50259265 | |||
| n/a | |||
| Name | BDBM50259265 | ||
| Synonyms: | CHEMBL4082297 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21N3O2 | ||
| Mol. Mass. | 335.3996 | ||
| SMILES | CC(C)(CN=C(c1ccccc1O)c1ccccc1O)c1c[nH]cn1 |(6.49,-2.55,;7.27,-3.89,;8.04,-2.55,;8.61,-4.66,;8.62,-6.2,;9.95,-6.97,;9.96,-8.51,;11.29,-9.27,;11.3,-10.82,;9.96,-11.59,;8.63,-10.82,;8.63,-9.28,;7.3,-8.51,;11.29,-6.19,;11.27,-4.66,;12.6,-3.88,;13.94,-4.65,;13.95,-6.19,;12.62,-6.96,;12.62,-8.5,;5.95,-4.67,;4.54,-4.04,;3.51,-5.19,;4.28,-6.52,;5.79,-6.2,)| | ||
| Structure | 
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