| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-2 |
|---|
| Ligand | BDBM50265078 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1692049 |
|---|
| Ki | 149±n/a nM |
|---|
| Citation |  Rouanet-Mehouas, C; Czarny, B; Beau, F; Cassar-Lajeunesse, E; Stura, EA; Dive, V; Devel, L Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity. J Med Chem60:403-414 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-2 |
|---|
| Name: | Stromelysin-2 |
|---|
| Synonyms: | MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54143.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09238 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
|
|
|
|---|
| BDBM50265078 |
|---|
| n/a |
|---|
| Name | BDBM50265078 |
|---|
| Synonyms: | (4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hydroxy)phosphoryl)-2-((3-(3'-chlorobiphenyl-4-yl)isoxazol-5-yl)methyl)propanamido)-4-carboxybutanamido)-5-oxopentanoic acid | CHEMBL507420 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H35BrClN4O10P |
|---|
| Mol. Mass. | 818.004 |
|---|
| SMILES | NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1cc(no1)-c1ccc(cc1)-c1cccc(Cl)c1)CP(O)(=O)c1ccc(Br)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
