Reaction Details |
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Target | G-protein coupled receptor 4 |
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Ligand | BDBM50260329 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1693561 |
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IC50 | 50±n/a nM |
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Citation | Miltz, W; Velcicky, J; Dawson, J; Littlewood-Evans, A; Ludwig, MG; Seuwen, K; Feifel, R; Oberhauser, B; Meyer, A; Gabriel, D; Nash, M; Loetscher, P Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorg Med Chem25:4512-4525 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled receptor 4 |
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Name: | G-protein coupled receptor 4 |
Synonyms: | G-protein coupled receptor 4 | G-protein coupled receptor 4 (GPR4) | GPR4 | GPR4_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 40994.40 |
Organism: | Homo sapiens (Human) |
Description: | P46093 |
Residue: | 362 |
Sequence: | MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLS
IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVA
HPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAW
MNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPY
HVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKA
LHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPP
AQ
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BDBM50260329 |
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n/a |
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Name | BDBM50260329 |
Synonyms: | CHEMBL4098400 |
Type | Small organic molecule |
Emp. Form. | C27H39N7O |
Mol. Mass. | 477.6449 |
SMILES | Cc1cc(nc(C)n1)N(Cc1ccc(cc1)-n1cc(CCN2CCC(O)CC2)nn1)CC(C)(C)C |
Structure |
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