| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled receptor 4 |
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| Ligand | BDBM50260328 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1693561 |
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| IC50 | 9100±n/a nM |
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| Citation |  Miltz, W; Velcicky, J; Dawson, J; Littlewood-Evans, A; Ludwig, MG; Seuwen, K; Feifel, R; Oberhauser, B; Meyer, A; Gabriel, D; Nash, M; Loetscher, P Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorg Med Chem25:4512-4525 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled receptor 4 |
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| Name: | G-protein coupled receptor 4 |
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| Synonyms: | G-protein coupled receptor 4 | G-protein coupled receptor 4 (GPR4) | GPR4 | GPR4_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40994.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46093 |
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| Residue: | 362 |
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| Sequence: | MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLS
IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVA
HPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAW
MNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPY
HVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKA
LHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPP
AQ
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| BDBM50260328 |
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| n/a |
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| Name | BDBM50260328 |
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| Synonyms: | CHEMBL4090675 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N5 |
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| Mol. Mass. | 403.563 |
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| SMILES | CCc1nc2cccnc2n1Cc1ccc(\C=C\CN2CCN(CC2)C(C)C)cc1 |
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| Structure | 
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