Reaction Details |
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Target | 5-hydroxytryptamine receptor 2C |
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Ligand | BDBM50260599 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1694219 |
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IC50 | 2.7±n/a nM |
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Citation | Xiamuxi, H; Wang, Z; Li, J; Wang, Y; Wu, C; Yang, F; Jiang, X; Liu, Y; Zhao, Q; Chen, W; Zhang, J; Xie, Y; Hu, T; Xu, M; Guo, S; Akber Aisa, H; He, Y; Shen, J Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics. Bioorg Med Chem25:4904-4916 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2C |
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Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51836.79 |
Organism: | Homo sapiens (Human) |
Description: | P28335 |
Residue: | 458 |
Sequence: | MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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BDBM50260599 |
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n/a |
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Name | BDBM50260599 |
Synonyms: | CHEMBL4094825 |
Type | Small organic molecule |
Emp. Form. | C23H24N4OS |
Mol. Mass. | 404.528 |
SMILES | Cc1nc2ccccn2c(=O)c1CCN1CCN(CC1)c1cccc2sccc12 |
Structure |
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