Ki Summary

Reaction Details

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Target

Aldo-keto reductase family 1 member B1

Ligand

BDBM50010447

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_218061

4300±n/a nM

Citation

Deck, LM; Vander Jagt, DL; Royer, RE Gossypol and derivatives: a new class of aldose reductase inhibitors. J Med Chem34:3301-5 (1991) [PubMed]

More Info.:

Get all data from this article, Assay Method

Aldo-keto reductase family 1 member B1

Name:

Aldo-keto reductase family 1 member B1

Synonyms:

Type:

Protein

Mol. Mass.:

35855.50

Organism:

Homo sapiens (Human)

Description:

P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0

Residue:

316

Sequence:

MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

BDBM50010447

n/a

Name

BDBM50010447

Synonyms:

8,8'-Bis-hydroxymethyl-5,5'-diisopropyl-1,1'-dimethoxy-3,3'-dimethyl-[2,2']binaphthalenyl-6,7,6',7'-tetraol | CHEMBL109497

Type

Small organic molecule

Emp. Form.

C32H38O8

Mol. Mass.

550.6393

SMILES

COc1c(c(C)cc2c(C(C)C)c(O)c(O)c(CO)c12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(CO)c2c1OC |(9.55,-8.26,;8.21,-9.03,;8.21,-10.58,;9.55,-11.35,;9.55,-12.91,;9.55,-14.01,;8.21,-13.65,;6.92,-12.91,;5.59,-13.65,;5.59,-15.21,;6.92,-15.98,;4.26,-15.98,;4.26,-12.91,;2.92,-13.69,;4.26,-11.35,;2.92,-10.58,;5.59,-10.58,;5.59,-9.03,;6.93,-8.26,;6.92,-11.35,;12.21,-11.35,;12.21,-12.91,;12.24,-14.01,;13.55,-13.65,;14.86,-12.91,;16.19,-13.65,;16.19,-15.21,;17.54,-15.98,;14.86,-15.98,;17.54,-12.91,;18.85,-13.69,;17.54,-11.35,;18.85,-10.58,;16.19,-10.58,;16.18,-9.03,;14.83,-8.26,;14.86,-11.35,;13.55,-10.58,;13.55,-9.03,;12.21,-8.26,)|

Structure