| Reaction Details |
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 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
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| Ligand | BDBM50261665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1696272 |
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| EC50 | 32±n/a nM |
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| Citation |  Sparks, SM; Spearing, PK; Diaz, CJ; Cowan, DJ; Jayawickreme, C; Chen, G; Rimele, TJ; Generaux, C; Harston, LT; Roller, SG Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration. Bioorg Med Chem Lett27:4673-4677 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Extracellular calcium-sensing receptor |
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| Name: | Extracellular calcium-sensing receptor |
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| Synonyms: | CASR | CASR_HUMAN | CaR | Calcium sensing receptor | Calcium-sensing receptor (CaSR) | Extracellular calcium-sensing receptor | GPRC2A | PCAR1 | Parathyroid Cell calcium-sensing receptor | Parathyroid cell calcium-sensing receptor 1 | Synonyms=GPRC2A | hCasR |
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| Type: | Protein |
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| Mol. Mass.: | 120663.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41180 |
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| Residue: | 1078 |
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| Sequence: | MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
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| BDBM50261665 |
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| n/a |
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| Name | BDBM50261665 |
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| Synonyms: | CHEMBL4082125 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N3O6 |
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| Mol. Mass. | 523.6206 |
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| SMILES | C[C@@H](N[C@H]1CCN(C1)c1ccc(cc1)C(=O)N(C)[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)CO)c1cccc2ccccc12 |r| |
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| Structure | 
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