| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 2 |
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| Ligand | BDBM50263221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1697717 |
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| Ki | >1000000±n/a nM |
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| Citation |  Brogi, S; Brindisi, M; Butini, S; Kshirsagar, GU; Maramai, S; Chemi, G; Gemma, S; Campiani, G; Novellino, E; Fiorenzani, P; Pinassi, J; Aloisi, AM; Gynther, M; Venskutonyt?, R; Han, L; Frydenvang, K; Kastrup, JS; Pickering, DS ( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation. J Med Chem61:2124-2130 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 2 |
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| Name: | Glutamate receptor ionotropic, kainate 2 |
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| Synonyms: | GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102478.61 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_936439 |
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| Residue: | 908 |
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| Sequence: | MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
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| BDBM50263221 |
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| n/a |
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| Name | BDBM50263221 |
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| Synonyms: | CHEMBL4077177 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H11N3O5 |
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| Mol. Mass. | 241.2007 |
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| SMILES | N[C@@H](Cn1c2COCc2c(=O)[nH]c1=O)C(O)=O |r| |
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| Structure | 
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