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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50263753 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1698247 (CHEMBL4049137) | ||
| IC50 | 3.1±n/a nM | ||
| Citation |  Obach, RS; Walker, GS; Sharma, R; Jenkinson, S; Tran, TP; Stepan, AF Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors. J Med Chem61:3626-3640 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
| ||
| BDBM50263753 | |||
| n/a | |||
| Name | BDBM50263753 | ||
| Synonyms: | CHEMBL4065163 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H17ClN6O | ||
| Mol. Mass. | 368.82 | ||
| SMILES | Cc1nn(C)c(c1-c1nc(C)c2n1nc(C)[nH]c2=O)-c1ccc(Cl)cc1 |(27.17,-14.96,;25.93,-15.87,;25.94,-17.41,;24.48,-17.89,;24,-19.36,;23.56,-16.65,;24.46,-15.4,;23.98,-13.94,;24.88,-12.68,;23.98,-11.44,;24.45,-9.98,;22.51,-11.92,;22.52,-13.46,;21.19,-14.23,;19.85,-13.47,;18.52,-14.25,;19.84,-11.93,;21.17,-11.15,;21.17,-9.61,;22.02,-16.65,;21.26,-15.32,;19.72,-15.32,;18.94,-16.66,;17.4,-16.67,;19.72,-17.99,;21.26,-17.99,)| | ||
| Structure | 
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