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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50263754 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1698247 (CHEMBL4049137) | ||
| IC50 | 28±n/a nM | ||
| Citation |  Obach, RS; Walker, GS; Sharma, R; Jenkinson, S; Tran, TP; Stepan, AF Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors. J Med Chem61:3626-3640 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
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| BDBM50263754 | |||
| n/a | |||
| Name | BDBM50263754 | ||
| Synonyms: | CHEMBL4100565 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H17ClN6O2 | ||
| Mol. Mass. | 384.82 | ||
| SMILES | Cc1nc(-c2c(CO)nn(C)c2-c2ccc(Cl)cc2)n2nc(C)[nH]c(=O)c12 |(26.26,-9.92,;25.78,-11.39,;26.7,-12.62,;25.8,-13.88,;26.28,-15.34,;27.74,-15.81,;28.99,-14.9,;30.4,-15.52,;27.75,-17.35,;26.29,-17.83,;25.82,-19.3,;25.38,-16.59,;23.84,-16.59,;23.06,-15.26,;21.52,-15.27,;20.76,-16.6,;19.22,-16.61,;21.53,-17.93,;23.07,-17.93,;24.33,-13.41,;23,-14.18,;21.67,-13.41,;20.33,-14.19,;21.66,-11.87,;22.99,-11.1,;22.98,-9.56,;24.32,-11.87,)| | ||
| Structure | 
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