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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50263765 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1698247 (CHEMBL4049137) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Obach, RS; Walker, GS; Sharma, R; Jenkinson, S; Tran, TP; Stepan, AF Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors. J Med Chem61:3626-3640 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
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| BDBM50263765 | |||
| n/a | |||
| Name | BDBM50263765 | ||
| Synonyms: | CHEMBL4074834 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H19N7O2 | ||
| Mol. Mass. | 365.3892 | ||
| SMILES | COc1ccc(cn1)-c1c(c(C)nn1C)-c1nc(C)c2n1nc(C)[nH]c2=O |(17.03,-22.44,;17.8,-21.11,;19.35,-21.11,;20.11,-19.77,;21.66,-19.77,;22.43,-21.11,;21.66,-22.44,;20.11,-22.44,;23.97,-21.11,;24.88,-19.86,;26.34,-20.33,;27.59,-19.43,;26.34,-21.88,;24.88,-22.35,;24.4,-23.82,;24.4,-18.39,;25.31,-17.14,;24.4,-15.9,;24.88,-14.43,;22.93,-16.37,;22.93,-17.92,;21.6,-18.69,;20.26,-17.92,;18.93,-18.69,;20.26,-16.37,;21.6,-15.61,;21.6,-14.06,)| | ||
| Structure | 
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