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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50263766 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1698247 (CHEMBL4049137) | ||
| IC50 | >2000±n/a nM | ||
| Citation |  Obach, RS; Walker, GS; Sharma, R; Jenkinson, S; Tran, TP; Stepan, AF Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors. J Med Chem61:3626-3640 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
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| BDBM50263766 | |||
| n/a | |||
| Name | BDBM50263766 | ||
| Synonyms: | CHEMBL4095278 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H15N7O2 | ||
| Mol. Mass. | 337.336 | ||
| SMILES | Cc1n[nH]c(c1-c1nc(C)c2n1nc(C)[nH]c2=O)-c1ccc(O)nc1 |(31.7,-13.41,;30.47,-14.33,;30.49,-15.87,;29.03,-16.36,;28.11,-15.13,;28.99,-13.87,;28.5,-12.41,;29.39,-11.16,;28.46,-9.92,;28.91,-8.45,;27,-10.42,;27.03,-11.96,;25.7,-12.75,;24.36,-12,;23.03,-12.78,;24.34,-10.45,;25.66,-9.66,;25.63,-8.13,;26.57,-15.16,;25.78,-13.83,;24.23,-13.85,;23.49,-15.2,;21.95,-15.22,;24.28,-16.52,;25.81,-16.5,)| | ||
| Structure | 
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