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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50263776 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1698247 (CHEMBL4049137) | ||
| IC50 | 19±n/a nM | ||
| Citation |  Obach, RS; Walker, GS; Sharma, R; Jenkinson, S; Tran, TP; Stepan, AF Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors. J Med Chem61:3626-3640 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
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| BDBM50263776 | |||
| n/a | |||
| Name | BDBM50263776 | ||
| Synonyms: | CHEMBL4095982 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H19N7O3 | ||
| Mol. Mass. | 381.3886 | ||
| SMILES | COc1ccc(cn1)-c1c(c(C)nn1C)-c1nc(CO)c2n1nc(C)[nH]c2=O |(15.41,-17.93,;16.18,-16.6,;17.72,-16.58,;18.48,-15.24,;20.02,-15.24,;20.8,-16.56,;20.04,-17.9,;18.49,-17.91,;22.34,-16.55,;23.24,-15.3,;24.71,-15.77,;25.95,-14.85,;24.72,-17.31,;23.26,-17.79,;22.79,-19.26,;22.75,-13.84,;23.64,-12.58,;22.73,-11.34,;23.2,-9.87,;22.16,-8.74,;21.27,-11.83,;21.28,-13.37,;19.95,-14.15,;18.61,-13.39,;17.29,-14.17,;18.61,-11.85,;19.94,-11.07,;19.92,-9.53,)| | ||
| Structure | 
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