| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50264822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1699174 (CHEMBL4050156) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Cernak, T; Gesmundo, NJ; Dykstra, K; Yu, Y; Wu, Z; Shi, ZC; Vachal, P; Sperbeck, D; He, S; Murphy, BA; Sonatore, L; Williams, S; Madeira, M; Verras, A; Reiter, M; Lee, CH; Cuff, J; Sherer, EC; Kuethe, J; Goble, S; Perrotto, N; Pinto, S; Shen, DM; Nargund, R; Balkovec, J; DeVita, RJ; Dreher, SD Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors. J Med Chem60:3594-3605 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM50264822 |
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| n/a |
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| Name | BDBM50264822 |
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| Synonyms: | CHEMBL4091946 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19F3N4O4 |
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| Mol. Mass. | 508.4487 |
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| SMILES | OC(=O)c1ccc2c(c1)C(=O)OC21CCN(CC1)c1ccc(cn1)-c1nc2cc(ccc2[nH]1)C(F)(F)F |
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| Structure | 
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