| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-III |
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| Ligand | BDBM50265599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1700084 (CHEMBL4051066) |
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| IC50 | 1900±n/a nM |
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| Citation |  Ito, M; Tanaka, T; Cary, DR; Iwatani-Yoshihara, M; Kamada, Y; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem60:3335-3351 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-III |
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| Name: | Eukaryotic initiation factor 4A-III |
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| Synonyms: | ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265 |
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| Type: | Protein |
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| Mol. Mass.: | 46871.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P38919 |
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| Residue: | 411 |
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| Sequence: | MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK
PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV
QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA
IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA
NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL
YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
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| BDBM50265599 |
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| n/a |
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| Name | BDBM50265599 |
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| Synonyms: | CHEMBL4097731 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19BrCl2N4O2 |
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| Mol. Mass. | 558.254 |
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| SMILES | Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2c(Br)cccc12 |
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| Structure | 
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