| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 1 |
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| Ligand | BDBM50148549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1998145 (CHEMBL4650002) |
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| IC50 | 1679±n/a nM |
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| Citation |  Bouché, L; Christ, CD; Siegel, S; Fernández-Montalván, AE; Holton, SJ; Fedorov, O; Ter Laak, A; Sugawara, T; Stöckigt, D; Tallant, C; Bennett, J; Monteiro, O; Díaz-Sáez, L; Siejka, P; Meier, J; Pütter, V; Weiske, J; Müller, S; Huber, KVM; Hartung, IV; Haendler, B Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J Med Chem60:4002-4022 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 1 |
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| Name: | Bromodomain-containing protein 1 |
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| Synonyms: | BR140-like protein | BRD1 | BRD1_HUMAN | BRL | BRL | BRPF2 | Bromodomain and PHD finger-containing protein 2 | Bromodomain-containing protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119557.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105349 |
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| Residue: | 1058 |
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| Sequence: | MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEII
LEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEP
KVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPA
VSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLA
VHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPE
VGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGL
YMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTV
RSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYW
LLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIE
LLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYL
DHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGG
VVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRE
LLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALG
PEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGL
GRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGN
YAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHN
GVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKM
MEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID
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| BDBM50148549 |
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| n/a |
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| Name | BDBM50148549 |
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| Synonyms: | 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide | 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide | CHEMBL3770173 | OF 1 | OF-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18BrN3O4S |
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| Mol. Mass. | 440.312 |
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| SMILES | COc1cc2n(C)c(=O)n(C)c2cc1NS(=O)(=O)c1ccc(Br)cc1C |
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| Structure | 
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