| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50011428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210731 |
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| IC50 | >2000000±n/a nM |
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| Citation |  Cushman, M; Nagarathnam, D; Burg, DL; Geahlen, RL Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. J Med Chem34:798-806 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50011428 |
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| n/a |
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| Name | BDBM50011428 |
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| Synonyms: | 2-(3,4,5-Trimethoxy-phenyl)-chromen-4-one | 2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one | CHEMBL307856 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16O5 |
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| Mol. Mass. | 312.3166 |
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| SMILES | COc1cc(cc(OC)c1OC)-c1cc(=O)c2ccccc2o1 |
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| Structure | 
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