Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50266541 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1700966 (CHEMBL4051948) |
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EC50 | 82±n/a nM |
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Citation | Lasalle, M; Hoguet, V; Hennuyer, N; Leroux, F; Piveteau, C; Belloy, L; Lestavel, S; Vallez, E; Dorchies, E; Duplan, I; Sevin, E; Culot, M; Gosselet, F; Boulahjar, R; Herledan, A; Staels, B; Deprez, B; Tailleux, A; Charton, J Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance. J Med Chem60:4185-4211 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | GPBAR_MOUSE | Gpbar1 | M-BAR | Membrane-type receptor for bile acids | Tgr5 |
Type: | PROTEIN |
Mol. Mass.: | 35665.78 |
Organism: | Mus musculus |
Description: | ChEMBL_1475560 |
Residue: | 329 |
Sequence: | MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAG
LLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPH
GSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGAT
ALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYV
ATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRV
LRGRAKRDNPGPSTAYHTSSQCSIDLDLN
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BDBM50266541 |
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n/a |
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Name | BDBM50266541 |
Synonyms: | CHEMBL4069569 |
Type | Small organic molecule |
Emp. Form. | C29H28F3N3O4S |
Mol. Mass. | 571.611 |
SMILES | COC(=O)CCc1nc(SCc2c(F)cccc2F)n(c1N(C)c1ccc(OC)c(OC)c1)-c1ccc(F)cc1 |
Structure |
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