| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled bile acid receptor 1 |
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| Ligand | BDBM50266540 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1700964 (CHEMBL4051946) |
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| EC50 | 4300±n/a nM |
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| Citation |  Lasalle, M; Hoguet, V; Hennuyer, N; Leroux, F; Piveteau, C; Belloy, L; Lestavel, S; Vallez, E; Dorchies, E; Duplan, I; Sevin, E; Culot, M; Gosselet, F; Boulahjar, R; Herledan, A; Staels, B; Deprez, B; Tailleux, A; Charton, J Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance. J Med Chem60:4185-4211 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled bile acid receptor 1 |
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| Name: | G-protein coupled bile acid receptor 1 |
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| Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 35260.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHO cells transiently transfected with hTGR5. |
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| Residue: | 330 |
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| Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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| BDBM50266540 |
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| n/a |
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| Name | BDBM50266540 |
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| Synonyms: | CHEMBL4102610 | US10323016, Example 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N4O2S |
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| Mol. Mass. | 486.509 |
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| SMILES | COc1ccc(cc1OC)N(C)c1nnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 |
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| Structure | 
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