| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain and PHD finger-containing protein 3 |
|---|
| Ligand | BDBM50249772 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1701776 (CHEMBL4053009) |
|---|
| IC50 | 7600±n/a nM |
|---|
| Citation |  Igoe, N; Bayle, ED; Fedorov, O; Tallant, C; Savitsky, P; Rogers, C; Owen, DR; Deb, G; Somervaille, TC; Andrews, DM; Jones, N; Cheasty, A; Ryder, H; Brennan, PE; Müller, S; Knapp, S; Fish, PV Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem60:668-680 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain and PHD finger-containing protein 3 |
|---|
| Name: | Bromodomain and PHD finger-containing protein 3 |
|---|
| Synonyms: | BRPF3 | BRPF3_HUMAN | Bromodomain and PHD finger-containing protein 3 | KIAA1286 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 135743.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_108004 |
|---|
| Residue: | 1205 |
|---|
| Sequence: | MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
TSSYL
|
|
|
|---|
| BDBM50249772 |
|---|
| n/a |
|---|
| Name | BDBM50249772 |
|---|
| Synonyms: | CHEMBL4067436 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14N2O3S |
|---|
| Mol. Mass. | 314.359 |
|---|
| SMILES | Cn1c2ccc(NS(=O)(=O)c3ccccc3)cc2ccc1=O |
|---|
| Structure | 
|
|---|
Search and Browse
