| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate synthase |
|---|
| Ligand | BDBM50011751 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_209808 |
|---|
| IC50 | 19±n/a nM |
|---|
| Citation |  Thornton, TJ; Jones, TR; Jackman, AL; Flinn, A; O'Connor, BM; Warner, P; Calvert, AH Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. J Med Chem34:978-84 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate synthase |
|---|
| Name: | Thymidylate synthase |
|---|
| Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 34957.15 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1340097 |
|---|
| Residue: | 307 |
|---|
| Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
|
|
|
|---|
| BDBM50011751 |
|---|
| n/a |
|---|
| Name | BDBM50011751 |
|---|
| Synonyms: | 2-{4-[(2-Amino-4-thioxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid | CHEMBL177931 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23N5O5S |
|---|
| Mol. Mass. | 493.535 |
|---|
| SMILES | Nc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=S)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
