| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor receptor |
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| Ligand | BDBM50011856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_154999 |
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| IC50 | 1000±n/a nM |
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| Citation |  Walser, A; Flynn, T; Mason, C; Crowley, H; Maresca, C; O'Donnell, M Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2. J Med Chem34:1440-6 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor receptor |
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| Name: | Platelet-activating factor receptor |
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| Synonyms: | PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39219.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PAF Platelet activating factor PTAFR HUMAN::P25105 |
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| Residue: | 342 |
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| Sequence: | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
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| BDBM50011856 |
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| n/a |
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| Name | BDBM50011856 |
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| Synonyms: | CHEMBL33217 | {5-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-3H-[1,2,3]triazol-4-yl}-morpholin-4-yl-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClN8O2S |
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| Mol. Mass. | 494.957 |
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| SMILES | Cc1nnc2CN=C(c3cc(sc3-n12)-c1nn[nH]c1C(=O)N1CCOCC1)c1ccccc1Cl |c:6| |
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| Structure | 
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