| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
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| Ligand | BDBM50268343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1704880 (CHEMBL4056113) |
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| IC50 | >10000±n/a nM |
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| Citation |  Bender, AM; Weiner, RL; Luscombe, VB; Ajmera, S; Cho, HP; Chang, S; Zhan, X; Rodriguez, AL; Niswender, CM; Engers, DW; Bridges, TM; Conn, PJ; Lindsley, CW Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Bioorg Med Chem Lett27:3576-3581 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M5 |
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| Name: | Muscarinic acetylcholine receptor M5 |
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| Synonyms: | ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 60161.80 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M5 CHRM5 RAT::P08911 |
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| Residue: | 531 |
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| Sequence: | MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQL
KTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNL
LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPD
ECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKK
REPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVT
TCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKY
FLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPN
LSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGY
WLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
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| BDBM50268343 |
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| n/a |
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| Name | BDBM50268343 |
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| Synonyms: | CHEMBL4096727 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26ClN5O2S |
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| Mol. Mass. | 435.971 |
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| SMILES | C[C@H]1CCCCN1c1ccc(nn1)N1CCN(CC1)S(=O)(=O)c1ccccc1Cl |r| |
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| Structure | 
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