| Reaction Details |
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 | Report a problem with these data |
| Target | dCTP pyrophosphatase 1 |
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| Ligand | BDBM50150052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1705780 (CHEMBL4057013) |
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| IC50 | 47±n/a nM |
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| Citation |  Llona-Minguez, S; Häggblad, M; Martens, U; Throup, A; Loseva, O; Jemth, AS; Lundgren, B; Scobie, M; Helleday, T Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines. Bioorg Med Chem Lett27:3897-3904 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| dCTP pyrophosphatase 1 |
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| Name: | dCTP pyrophosphatase 1 |
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| Synonyms: | DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1) |
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| Type: | Protein |
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| Mol. Mass.: | 18673.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H773 |
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| Residue: | 170 |
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| Sequence: | MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
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| BDBM50150052 |
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| n/a |
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| Name | BDBM50150052 |
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| Synonyms: | CHEMBL3771105 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17BCl2N4O6 |
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| Mol. Mass. | 491.089 |
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| SMILES | CN1CC(=O)OB(OC(=O)C1)c1ccc(Cn2c(C)nc3c(c(Cl)c(Cl)cc23)[N+]([O-])=O)cc1 |
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| Structure | 
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