| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM8964 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1705909 (CHEMBL4057142) |
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| IC50 | 16900±n/a nM |
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| Citation |  Schmidt, I; Göllner, S; Fuß, A; Stich, A; Kucharski, A; Schirmeister, T; Katzowitsch, E; Bruhn, H; Miliu, A; Krauth-Siegel, RL; Holzgrabe, U Bistacrines as potential antitrypanosomal agents. Bioorg Med Chem25:4526-4531 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM8964 |
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| n/a |
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| Name | BDBM8964 |
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| Synonyms: | CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]-1,2,3,4-tetrahydroacridin-9-amine | Tacrine Dimer 3c | Tacrine-Based Inhibitor 2g |
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| Type | Small organic molecule |
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| Emp. Form. | C34H42N4 |
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| Mol. Mass. | 506.7241 |
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| SMILES | C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 |
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| Structure | 
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