| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Srms |
|---|
| Ligand | BDBM50269555 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1706739 (CHEMBL4057972) |
|---|
| IC50 | 65±n/a nM |
|---|
| Citation |  Boga, SB; Alhassan, AB; Liu, J; Guiadeen, D; Krikorian, A; Gao, X; Wang, J; Yu, Y; Anand, R; Liu, S; Yang, C; Wu, H; Cai, J; Zhu, H; Desai, J; Maloney, K; Gao, YD; Fischmann, TO; Presland, J; Mansueto, M; Xu, Z; Leccese, E; Knemeyer, I; Garlisi, CG; Bays, N; Stivers, P; Brandish, PE; Hicks, A; Cooper, A; Kim, RM; Kozlowski, JA Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis. Bioorg Med Chem Lett27:3939-3943 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Srms |
|---|
| Name: | Tyrosine-protein kinase Srms |
|---|
| Synonyms: | C20orf148 | SRC | SRMS | SRMS_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54517.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_18250298 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY
DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW
YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY
LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY
FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI
VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD
GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF
TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL
HAIHRCHP
|
|
|
|---|
| BDBM50269555 |
|---|
| n/a |
|---|
| Name | BDBM50269555 |
|---|
| Synonyms: | CHEMBL4060757 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27F4N7O3 |
|---|
| Mol. Mass. | 585.5527 |
|---|
| SMILES | Nc1nccn2c(nc(-c3ccc(cc3F)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@H]1CN(CCO1)C1CCOCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
