| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fgr |
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| Ligand | BDBM50269615 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1706898 (CHEMBL4058131) |
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| IC50 | 133±n/a nM |
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| Citation |  He, L; Li, D; Zhang, C; Bai, P; Chen, L Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC. Bioorg Med Chem Lett27:4171-4175 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fgr |
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| Name: | Tyrosine-protein kinase Fgr |
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| Synonyms: | FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr |
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| Type: | protein |
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| Mol. Mass.: | 59469.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09769 |
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| Residue: | 529 |
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| Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
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| BDBM50269615 |
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| n/a |
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| Name | BDBM50269615 |
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| Synonyms: | CHEMBL4095253 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O4S |
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| Mol. Mass. | 427.477 |
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| SMILES | Nc1ncnc2n(C[C@H]3CCCN3S(=O)(=O)C=C)cc(-c3ccc4OCOc4c3)c12 |r| |
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| Structure | 
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