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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50269753 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_1707178 | ||
| IC50 | 10.0±n/a nM | ||
| Citation |  Anan, K; Masui, M; Hara, S; Ohara, M; Kume, M; Yamamoto, S; Shinohara, S; Tsuji, H; Shimada, S; Yagi, S; Hasebe, N; Kai, H Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach. Bioorg Med Chem Lett27:4194-4198 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | Glutamate receptor ionotropic, NMDA 2B | Grin2b | Ionotropic glutamate receptor NMDA1/2B | N-methyl D-aspartate receptor subtype 2B | NMDAR2B | NMDE2_MOUSE | NR2B | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 165965.49 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_117725 | ||
| Residue: | 1482 | ||
| Sequence: |
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| BDBM50269753 | |||
| n/a | |||
| Name | BDBM50269753 | ||
| Synonyms: | CHEMBL4103672 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28N2O3 | ||
| Mol. Mass. | 392.4907 | ||
| SMILES | O[C@]1(CC(=O)Nc2ccc3NC(=O)CCc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,19.21,(14.58,-10.29,;15.35,-11.63,;13.81,-11.63,;13.04,-12.96,;13.81,-14.3,;11.5,-12.96,;10.73,-14.3,;11.51,-15.62,;10.75,-16.95,;9.2,-16.96,;8.43,-18.3,;6.89,-18.3,;6.12,-19.63,;6.11,-16.96,;6.89,-15.62,;8.42,-15.62,;9.2,-14.29,;16.68,-10.85,;18.01,-11.63,;18.01,-13.17,;19.34,-13.94,;20.68,-13.17,;22.01,-13.95,;23.34,-13.18,;23.35,-11.64,;22,-10.87,;20.68,-11.64,;16.68,-13.93,;15.35,-13.17,)| | ||
| Structure | 
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