| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM312082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1707498 (CHEMBL4058731) |
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| IC50 | 3400±n/a nM |
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| Citation |  Crosignani, S; Bingham, P; Bottemanne, P; Cannelle, H; Cauwenberghs, S; Cordonnier, M; Dalvie, D; Deroose, F; Feng, JL; Gomes, B; Greasley, S; Kaiser, SE; Kraus, M; Négrerie, M; Maegley, K; Miller, N; Murray, BW; Schneider, M; Soloweij, J; Stewart, AE; Tumang, J; Torti, VR; Van Den Eynde, B; Wythes, M Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J Med Chem60:9617-9629 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM312082 |
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| n/a |
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| Name | BDBM312082 |
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| Synonyms: | 3-(6-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione | US9603836, Compound 17 | US9949951, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9FN2O2 |
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| Mol. Mass. | 232.2105 |
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| SMILES | Fc1ccc2c(c[nH]c2c1)C1CC(=O)NC1=O |
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| Structure | 
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