Reaction Details |
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Target | Indoleamine 2,3-dioxygenase 1 |
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Ligand | BDBM73346 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1707498 (CHEMBL4058731) |
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IC50 | 3000±n/a nM |
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Citation | Crosignani, S; Bingham, P; Bottemanne, P; Cannelle, H; Cauwenberghs, S; Cordonnier, M; Dalvie, D; Deroose, F; Feng, JL; Gomes, B; Greasley, S; Kaiser, SE; Kraus, M; Négrerie, M; Maegley, K; Miller, N; Murray, BW; Schneider, M; Soloweij, J; Stewart, AE; Tumang, J; Torti, VR; Van Den Eynde, B; Wythes, M Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J Med Chem60:9617-9629 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Indoleamine 2,3-dioxygenase 1 |
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Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM73346 |
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n/a |
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Name | BDBM73346 |
Synonyms: | 3-(1H-indol-3-yl)-2,5-pyrrolidinedione | 3-(1H-indol-3-yl)pyrrolidine-2,5-dione | 3-(1H-indol-3-yl)pyrrolidine-2,5-quinone | MLS000099368 | SMR000071516 | US9603836, Compound 3 | US9949951, 3 | cid_363326 |
Type | Small organic molecule |
Emp. Form. | C12H10N2O2 |
Mol. Mass. | 214.22 |
SMILES | O=C1CC(C(=O)N1)c1c[nH]c2ccccc12 |
Structure |
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