| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 7 |
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| Ligand | BDBM50209660 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1708474 (CHEMBL4118523) |
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| IC50 | 4.6±n/a nM |
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| Citation |  Tan, L; Gurbani, D; Weisberg, EL; Jones, DS; Rao, S; Singer, WD; Bernard, FM; Mowafy, S; Jenney, A; Du, G; Nonami, A; Griffin, JD; Lauffenburger, DA; Westover, KD; Sorger, PK; Gray, NS Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Bioorg Med Chem25:1320-1328 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 7 |
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| Name: | Mitogen-activated protein kinase kinase kinase 7 |
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| Synonyms: | M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1) |
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| Type: | Protein |
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| Mol. Mass.: | 67199.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43318 |
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| Residue: | 606 |
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| Sequence: | MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS
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| BDBM50209660 |
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| n/a |
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| Name | BDBM50209660 |
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| Synonyms: | CHEMBL3884281 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN6O3 |
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| Mol. Mass. | 440.883 |
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| SMILES | Clc1cnc(Nc2cnn(c2)C2CCOCC2)nc1Oc1ccccc1NC(=O)C=C |
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| Structure | 
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